Polynucleotides (Salmon DNA) for Skin: What It Is, and How It Differs from Mesotherapy & PRP

What are polynucleotides?

Polynucleotides (PN) are injectable bio-regeneration molecules, usually purified to high grade from salmon or trout DNA. They stimulate fibroblasts in the deeper skin to support collagen/elastin production, hydration and micro-circulation. Often marketed as "salmon DNA."

Key distinction: PN is not a filler. It adds no volume and changes no contour. What it does is improve skin quality — texture, hydration, elasticity, glow.

How it differs from mesotherapy and PRP

These three are complementary, not competing; which suits you depends on the skin need — see our face mesotherapy vs PRP decision-matrix post.

Where is it used?

• Overall skin quality and glow
• Fine lines and early ageing signs
• Thin under-eye skin quality (in suitable candidates)
• Thin-skin areas like neck and back of hands
• "Skin prep" combined with filler/other procedures

Session plan

• Initial course: typically 2–4 sessions, 2–4 weeks apart.
• Maintenance: every 6–12 months.
• Results are gradual; skin-quality change is usually clearer as the course progresses.

The procedure takes 20–30 minutes, well tolerated with topical anaesthetic. Mild redness/blebs afterwards last hours to a couple of days.

Who is unsuitable / cautions

• Caution with fish/seafood allergy (the source DNA is fish-derived) — always tell your physician.
• Not performed in pregnancy/breastfeeding.
• Deferred if there is active infection at the site.
• The product must be TİTCK-approved and sourced through original channels.

FAQ

“Is it a substitute for filler?” No. PN adds no volume; it improves quality. Filler for volume, PN for quality — they can be planned together.

“When will I see results?” Usually a glow within 2–4 weeks; clearer tissue-quality improvement by the end of the course.

“How many sessions?” Most need a 2–4 session initial course plus maintenance. A single session is not curative.